Slug expression during organogenesis in mice
نویسندگان
چکیده
منابع مشابه
Notch gene expression during pancreatic organogenesis
Notch receptors are involved in regulating the balance between cell differentiation and stem cell proliferation during the development of numerous tissues (Artavanis-Tsakonas, S., Matsuno, K., Fortini, M. E., 1995. Notch signaling. Science 268, 225-232). Here the expression of all four vertebrate Notch genes, their ligands, and some down-stream targets is analyzed during mouse pancreatic organo...
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Mammalian Pbx genes (Pbx1-3) encode a family of TALE homeodomain proteins that function as transcriptional regulators in numerous cell types (Curr. Opin. Genet. Dev. 8 (1998) 423). The present study highlights distinctive features of Pbx1b expression during mouse embryonic development as a framework to understand its biological functions. Immunohistochemical analyses demonstrate extensive expre...
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Nonmetastatic (nm) 23 gene expression correlates inversely with metastatic potential in several rodent tumor model systems as well as in human infiltrating ductal breast and hepatocellular carcinomas. Since tumor cell invasion and metastasis involve many processes exhibited by normal cells during development, we investigated whether nm23 is expressed during mouse embryogenesis. Northern blot an...
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BACKGROUND Cardiovascular and neural malformations are common sequels of diabetic pregnancies, but the underlying molecular mechanisms remain unknown. We hypothesized that maternal hyperglycemia would affect the embryos most shortly after the glucose-sensitive time window at embryonic day (ED) 7.5 in mice. METHODS Mice were made diabetic with streptozotocin, treated with slow-release insulin ...
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Reepithelialization during cutaneous wound healing involves numerous signals that result in basal keratinocyte activation, spreading, and migration, all linked to a loosening of cell-cell adhesion structures. The transcription factor Slug is required for this process, and EGF treatment of human keratinocytes induced activating phosphorylation of Erk5 that coincides with slug transcription. Acco...
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ژورنال
عنوان ژورنال: The Anatomical Record
سال: 2003
ISSN: 0003-276X,1097-0185
DOI: 10.1002/ar.a.10027